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	Provedor de dados BJMBR (1) Autor Gu,C.G. (1) Liu,C. (1) Luo,H. (1) Shui,C.L. (1) Wang,Q. (1) Palavra-chave Bladder cancer (1) Cell permeability (1) Hypoxia inducible factor-1α (1) VEGF (1) YC-1 (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Mechanism of hif-1α mediated hypoxia-induced permeability changes in bladder endothelial cells BJMBR Liu,C.; Shui,C.L.; Wang,Q.; Luo,H.; Gu,C.G.. This study aimed to investigate the mechanism of hypoxia-inducible factor-1 alpha (HIF-1α) mediated hypoxia-induced permeability changes in bladder endothelial cells. Models of in vitro hypoxic cell culture of bladder cancer, bladder cancer cells with low HIF-1α expression and HIF-1α RNA interference (RNAi) expression vector were established. Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to detect the expression of HIF-1α and vascular endothelial growth factor (VEGF) in each group. Bladder cell permeability was determined. Results showed that protein and mRNA expression of HIF-1α and VEGF at 3 and 12 h of hypoxia were significantly higher than normal control (P<0.05), and peaked at 12 h. HIF-1α and VEGF expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bladder cancer; Hypoxia inducible factor-1α; VEGF; Cell permeability; YC-1. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200616 Registros recuperados: 1 Primeira ... 1 ... Última

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